William N. Kelley, MD, MACP, MACR

William Kelley

Title: Professor of Medicine
Company: University of Pennsylvania
Location: Vero Beach, Florida, United States

William N. Kelley, MD, MACP, Professor of Medicine at the University of Pennsylvania, has been recognized by Marquis Who’s Who Top Doctors for dedication, achievements, and leadership in internal medicine.

Amassing more than five decades of professional experience, Dr. Kelley is a venerated and accomplished physician who has been serving as Professor of Medicine at the University of Pennsylvania since 1989. Alongside this role, he was the Executive Vice President of the University for Medical Affairs, chief executive officer of the University of Pennsylvania Medical Center and Health System and dean of the School of Medicine at the University of Pennsylvania from 1989 to 2000. Prior to these appointments, he was a professor of internal medicine, chairman of the department of internal medicine, and professor of biological chemistry at the School of Medicine at the University of Michigan from 1975 to 1989, as well as a professor of medicine, associate professor of biochemistry, assistant professor of biochemistry, and chief of the division on rheumatic and genetic diseases at Duke University from 1968 to 1975. He commenced his career at the National Institutes of Health as a clinical associate in the section on human biochemical genetics in the Arthritis and Rheumatic Branch between 1965 and 1967 and a teaching fellow of medicine at Harvard University from 1967 to 1968.

Alongside his primary endeavors, Dr. Kelley has been on the board of directors of Transenterix, Inc., since 2015, having previously served on the board of directors of GenVec, Inc., Merck & Company, Beckman Coulter, Inc., Polymedix, Inc., Advanced Biosurfaces, Inc., and Channel Health, Inc.. In addition, he served the National Institutes of Health in a multitude of capacities, including as a member of the director’s advisory committee, the Advisory Council of the NIDDK, the recombinant DNA committee and its human gene therapy subcommittee, as well as on several study sections. He was a former trustee of Emory University and the Woodruff Health Sciences Center at Emory University.

To prepare for his illustrious career, Dr. Kelley pursued a formal education at Emory University, where he earned a Doctor of Medicine with honors in 1963. He subsequently completed an internship and residency in medicine at Parkland Memorial Hospital from 1963 to 1965, becoming senior resident of medicine at the Massachusetts General Hospital from 1967 to 1968. Later, he was awarded an honorary master’s degree from the University of Pennsylvania in 1989.  Dr. Kelley is a diplomate of the American Board of Internal Medicine. He was later to serve as Chairman of the American Board of Internal Medicine.

Dr. Kelley maintains affiliation with several organizations, including the American Society for Clinical Investigation, where he served as president from 1983 to 1984 and the American Federation for Clinical Research where he was president from 1979 to 1980. He previously held several roles with the National Academy of Medicine (previously the Institute of Medicine), where he was elected to membership in 1985. He was an elected member of the governing council from 1996 to 2001, chairman of the membership committee from 1990 to 1994, and chairman of section four of the Institute of Medicine between 1988 and 1990. Additionally, he was the former president of the American College of Rheumatology and of the Central Rheumatism Society and a member of the Association of American Physicians, American Society of Internal Medicine, the American Society of Human Genetics, the Australian Rheumatism Association (honorary), and the Royal College of Physicians of Ireland (honorary),  among others.

Dr. Kelley published over 350 articles in professional journals and previously served on the editorial boards of 13 journals including the Journal of Clinical Investigation, the Journal of Biological Chemistry, and the Annals of Internal Medicine. He was the co-founder and Editor-in-Chief of the Textbook of Rheumatology for its first 5 editions; for the next 4 editions it was referred to as Kelley’s Textbook of Rheumatology, and now in its 10th edition, it is Kelley and Firestein’s Textbook of Rheumatology.  He was the founder and editor-in-chief of the Textbook of Internal Medicine,” which is currently in its fourth edition as Kelley’s Textbook of Internal Medicine. He has additionally served as editor-in-chief of “Essentials of Internal Medicine” as well as the co-editor of “Arthritis Surgery” and co-author of books entitled  “Uric Acid,” “Gout and Hyperuricemia,” and “Emerging Policies for Bio-Medical Research,” respectively.

In recognition of his exceptional contributions to the field of medicine, Dr. Kelley has accrued many accolades throughout his impressive career. He was the recipient of the Kober Medal from the Association of American Physicians in 2005, the David E. Rogers Award from the Association of American Medical Colleges in 1999, the Gold Medal Award from the American College of Rheumatology in 1997, and the Robert H. Williams Award from the Association of Professors of Medicine in 1995. In addition, the National Health Council awarded him the National Medical Research Award in 1993, the American College of Physicians awarded him the John Phillips Memorial Award and Medal in 1990, and Emory University gave him a Distinguished Medical Achievement Award in 1985 as well as the Emory Medal in 2000. Notably, Dr. Kelley is a fellow of the American Association for the Advancement of Science, and an elected member of the American Philosophical Society, and the American Academy of Arts and Sciences. He also was awarded masterships by the American College of Physicians and by the American College of Rheumatology.

Dr. Kelley is renowned for helping in the establishment of the first proof of principal of in vivo gene therapy alongside Dr. Tom Palella and Dr. Myron Levine as documented by the patent entitled “Viral-mediated Gene Transfer System” which was submitted in December 1987 and which was issued by the U.S. Patent office in 1997 (USPTO # 5,672,344). He later was to play a major role in building one of the strongest gene therapy programs in the world at the University of Pennsylvania and its affiliate health systems. This was done primarily by his ability to recruit hugely talented physician scientists to Penn in the 1990s who were committed to the concept that gene therapy could be used to cure human disease.

For more:

University of Pennsylvania

The Business of Personalized Medicine

Lifetime Achievement

Contact Dr. Kelley


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